Nonrelapsing Secondary Progressive Multiple Sclerosis (NRSPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (HERCULES)

Trial Identifier: EFC16645
Sponsor: Sanofi
Start Date: September 2020
Primary Completion Date: August 2024
Study Completion Date: August 2024

Trial Locations

Country Location
Argentina Córdoba, Argentina, 5000
Argentina San Miguel de Tucuman, Argentina, T4000AXL
Argentina, Buenos Aires Buenos Aires, Argentina, 1860
Argentina, Buenos Aires Capital Federal, Buenos Aires, Argentina, 1012
Argentina, Ciudad de Buenos Aires CABA, Ciudad de Buenos Aires, Argentina, C1061
Australia, Queensland Woolloongabba, Queensland, Australia, 4102
Australia, South Australia Kent Town, South Australia, Australia
Australia, Tasmania Hobart, Tasmania, Australia, 7001
Australia, Victoria Fitzroy, Victoria, Australia, 3065
Australia, Victoria Heidelberg West, Victoria, Australia, 3081
AUSTRALIA, New South Wales St Leonards, New South Wales, AUSTRALIA, 2065
Austria Innsbruck, Austria, 6020
Austria Linz, Austria, 4021
Austria Linz, Austria, 4020
Austria Wien, Austria, 1090
Belarus Vitebsk, Belarus, 210037
Belarus Vitebsk, Belarus, 210009
Belgium Bruxelles, Belgium, 1200
Belgium Edegem, Belgium, B-2650
Belgium LEUVEN, Belgium, 3000
Belgium Liège, Belgium, 4000
Belgium Mons, Belgium, 7000
Belgium Pelt, Belgium, 3900
BELGIUM Bruxelles, BELGIUM, 1070
BELGIUM Gent, BELGIUM, 9000
Bulgaria Pleven, Bulgaria, 5800
Bulgaria Plovdiv, Bulgaria, 4000
Bulgaria Sofia, Bulgaria, 1431
Bulgaria Sofia, Bulgaria, 1407
Bulgaria Sofia, Bulgaria, 1113
Bulgaria Sofia, Bulgaria, 1680
Canada, British Columbia Burnaby, British Columbia, Canada, V5G 2X6
Canada, Nova Scotia Halifax, Nova Scotia, Canada, B3H 1V7
Canada, Ontario Ottawa, Ontario, Canada, K1H 8L6
Canada, Ontario Toronto, Ontario, Canada, M4N 3M5
Canada, Quebec Gatineau, Quebec, Canada, J8Y 1W2
Canada, Quebec Greenfield Park, Quebec, Canada, J4V 2J2
Canada, Quebec Montreal, Quebec, Canada, H2X 0A9
Canada, Quebec Montreal, Quebec, Canada, H3A 2B4
Canada, Quebec Quebec, Canada, G1W 4R4
Canada, Quebec Sherbrooke, Quebec, Canada, J1H 5N4
CANADA, Quebec Quebec, CANADA, G1J 1Z4
China Beijing, China, 100053
China Beijing, China, 100730
China Beijing, China, 100034
China Beijing, China, 100700
China Changchun, China, 130021
China Changsha, China, 410008
China Chengdu, China, 610041
China Chongqing, China, 400016
China Fuzhou, China, 350005
China Guangzhou, China, 510630
China Hangzhou, China, 310009
China Shijiazhuang, China, 050000
China Taiyuan, China, 030001
China Xi'an, China, 710038
Czechia Brno, Czechia, 65691
Czechia Hradec Kralove, Czechia, 50005
Czechia Jihlava, Czechia, 58633
Czechia Ostrava - Poruba, Czechia, 70852
Czechia Praha 2, Czechia, 12808
Czechia Teplice, Czechia, 415 29
Denmark Esbjerg, Denmark, 6700
Denmark Holstebro, Denmark, 7500
Denmark Odense, Denmark, 5000
Finland Helsinki, Finland, 00180
Finland Tampere, Finland, 33520
Finland Turku, Finland, 20520
France BRON, France, 69500
France Clermont Ferrand, France, 63003
France Gonesse, France, 95500
France Lille, France, 59037
France Montpellier, France, 34295
France Nancy, France, 54035
France NANTES, France, 44093
France Nimes, France, 30029
France PARIS, France, 75012
France PARIS, France, 75019
France PARIS, France, 75013
France RENNES, France, 35033
France STRASBOURG, France, 67098
France TOULOUSE, France, 31059
Germany Bayreuth, Germany, 95445
Germany Berlin, Germany, 10117
Germany Dresden, Germany, 01307
Germany Essen, Germany, 45147
Germany Gießen, Germany, 35385
Germany Halle (Saale), Germany, 06120
Germany Hannover, Germany, 30625
Germany Münster, Germany, 48149
Germany Rostock, Germany, 18055
Germany Ulm, Germany, 89081
Greece Athens, Greece, 15125
Greece Athens, Greece, 11535
Greece Athens, Greece, 12462
Greece Athens, Greece, 115 28
Greece Larissa, Greece, 41110
Greece Thessaloniki, Greece, 57010
Greece Thessaloniki, Greece, 546 36
Hungary Budapest, Hungary, 1135
Hungary Budapest, Hungary, 1152
Hungary Budapest, Hungary, 1145
Hungary Pécs, Hungary, 7623
Hungary Szeged, Hungary, 6725
Hungary Tatabánya, Hungary, 2800
India Gurgaon, India, 122001
India Gurgaon, India, 122002
India India, India
India Mangaluru, India, 575018
India New Delhi, India, 110060
India New Delhi, India, 110029
INDIA Nagpur, INDIA, 440012
Israel Ashkelon, Israel, 78278
Israel Haifa, Israel, 31096
Israel Jerusalem, Israel, 91120
Israel Tel HaShomer, Israel, 52621
Israel Zefat, Israel, 13100
Italy, Bergamo Bergamo, Italy, 24127
Italy, Cagliari Cagliari, Italy, 09126
Italy, Firenze Firenze, Italy, 50141
Italy, Firenze Firenze, Italy, 50134
Italy, Genova Genova, Italy, 16132
Italy, L'Aquila L'Aquila, Italy, 67010
Italy, Milano Milano, Italy, 20122
Italy, Milano Milano, Italy, 20132
Italy, Milano Milano, Italy, 20133
Italy, Pavia Pavia, Italy, 27100
Italy, Roma Roma, Italy, 00152
Italy, Roma Roma, Italy, 00168
Japan, Chiba Chiba-shi, Chiba, Japan, 260-8677
Japan, Iwate Morioka-shi, Iwate, Japan, 020-8505
Japan, Kyoto Kyoto-shi, Kyoto, Japan, 616-8255
Japan, Miyagi Sendai-shi, Miyagi, Japan, 980-8574
Japan, Niigata Niigata-shi, Niigata, Japan, 951-8520
Japan, Not Known Sagamihara-shi, Not Known, Japan, 252-0392
Japan, Osaka Moriguchi-shi, Osaka, Japan, 570-8507
Japan, Osaka Osaka-shi, Osaka, Japan, 556-0016
Japan, Saitama Kawagoe-shi, Saitama, Japan, 350-8550
Japan, Tokyo Kodaira-shi, Tokyo, Japan, 187-8551
Japan, Tokyo Ota-ku, Tokyo, Japan, 146-0065
Japan, Yamaguchi Ube-shi, Yamaguchi, Japan, 755-8505
Lithuania Kaunas, Lithuania, 50161
Lithuania Klaipeda, Lithuania, 92288
Lithuania Vilnius, Lithuania, 08661
Netherlands Amsterdam, Netherlands, 1081 GN
Netherlands Breda, Netherlands, 4818 CK
Netherlands Groningen, Netherlands, 9728 NZ
Netherlands Sittard-Geleen, Netherlands, 6162 BG
Norway Bergen, Norway, 5021
Norway Namsos, Norway, 7800
Norway Oslo, Norway, 0450
Poland Lodz, Poland, 90-549
Poland Lublin, Poland, 20-016
Poland Zabrze, Poland, 41-800
Poland, Kujawsko-pomorskie Bydgoszcz, Kujawsko-pomorskie, Poland, 85-796
Poland, Mazowieckie Warszawa, Mazowieckie, Poland, 01-211
Poland, Mazowieckie Warszawa, Mazowieckie, Poland, 01-684
Poland, Slaskie Katowice, Slaskie, Poland, 40-686
Poland, Slaskie Katowice, Slaskie, Poland, 40-684
Poland, Slaskie Katowice, Slaskie, Poland, 40-571
Poland, Wielkopolskie Plewiska, Wielkopolskie, Poland, 62-064
Portugal Braga, Portugal, 4710-243
Portugal Lisboa, Portugal, 1649-035
Portugal Lisboa, Portugal, 1162-050
Portugal Lisboa, Portugal, 1349-019
Portugal Matosinhos, Portugal, 4464-513
Portugal Porto, Portugal, 4099-001
Romania Bucuresti, Romania, 022328
Romania Campulung, Romania, 115100
Romania Cluj-Napoca, Romania, 400012
Romania Constanta, Romania, 900123
Romania Oradea, Romania, 410154
Romania Sibiu, Romania, 550052
Romania Targu Mures, Romania, 540136
Romania Timisoara, Romania, 300736
Russia Barnaul, Russia, 656024
Russia Ekaterinburg, Russia, 620102
Russia Kaliningrad, Russia, 236035
Russia Kazan, Russia, 420021
Russia Kemerovo, Russia, 650099
Russia Kirov, Russia, 610998
Russia Krasnoyarsk, Russia, 660029
Russia Moscow, Russia, 117997
Russia Moscow, Russia, 127015
Russia Moscow, Russia, 125367
Russia Moscow, Russia, 129128
Russia Moscow, Russia, 129110
Russia Nizhny Novgorod, Russia, 603137
Russia Nizhny Novgorod, Russia, 603155
Russia Novosibirsk, Russia, 630087
Russia Perm, Russia, 614990
Russia Pyatigorsk, Russia, 357538
Russia Rostov-on-Don, Russia, 344022
Russia Saint-Petersburg, Russia, 197110
Russia Samara, Russia, 443095
Russia Saransk, Russia, 430032
Russia Smolensk, Russia, 214018
Russia St-Petersburg, Russia, 197022
Russia Tyumen, Russia, 625000
Russia Ufa, Russia, 450005
Spain Córdoba, Spain, 14004
Spain Lleida, Spain, 25198
Spain Málaga, Spain, 29010
Spain, Andalucia Sevilla, Andalucia, Spain, 41009
Spain, Barcelona [Barcelona] Barcelona, Barcelona [Barcelona], Spain, 08036
Spain, Barcelona [Barcelona] Barcelona, Barcelona [Barcelona], Spain, 08035
Spain, Girona [Gerona] Salt, Girona [Gerona], Spain, 17190
Spain, Las Palmas Las Palmas de Gran Canaria, Las Palmas, Spain, 35010
Spain, Madrid Madrid, Spain, 28034
Spain, Madrid Madrid, Spain, 28040
Spain, Madrid Madrid, Spain, 28007
Spain, Madrid Majadahonda, Madrid, Spain, 28222
Spain, Madrid Pozuelo De Alarcón, Madrid, Spain, 28223
Spain, Murcia Murcia, Spain, 30120
Spain, Pais Vasco Donostia, Pais Vasco, Spain, 20014
Spain, Valencia Valencia, Spain, 46026
Turkey Eskisehir, Turkey
Turkey Hatay, Turkey
Turkey Istanbul, Turkey, 34896
Turkey Istanbul, Turkey
Turkey Istanbul, Turkey, 34688
Turkey Istanbul, Turkey, 34785
Turkey Istanbul, Turkey, 34098
Turkey Izmir, Turkey, 35100
Turkey Izmit, Turkey, 41380
Turkey Kütahya, Turkey, 43100
Turkey Mersin, Turkey, 33070
Turkey Trabzon, Turkey, 61080
Ukraine Chernivtsi, Ukraine, 58000
Ukraine Chernivtsi, Ukraine, 58023
Ukraine Dnipro, Ukraine, 49005
Ukraine Ivano-Frankivsk, Ukraine, 76018
Ukraine Kharkiv, Ukraine, 61068
Ukraine Kharkiv, Ukraine, 61103
Ukraine Kyiv, Ukraine, 03115
Ukraine Lutsk, Ukraine, 43005
Ukraine Lviv, Ukraine, 79010
Ukraine Lviv, Ukraine, 79013
Ukraine Odesa, Ukraine, 65025
Ukraine Vinnytsia, Ukraine, 21050
Ukraine Zhytomyr, Ukraine, 10002
United Kingdom Bristol, United Kingdom, BS10 5NB
United Kingdom Cardiff, United Kingdom, CF4 4XY
United Kingdom London, United Kingdom, SW17 0RE
United Kingdom London, United Kingdom, W6 8RF
United Kingdom, Devon Exeter, Devon, United Kingdom, EX2 5DW
United Kingdom, Devon Plymouth, Devon, United Kingdom, PL6 8DH
United Kingdom, Neath Port Talbot Swansea, Neath Port Talbot, United Kingdom, SA6 6NL
United Kingdom, Newcastle upon Tyne Newcastle Upon Tyne, Newcastle upon Tyne, United Kingdom, NE1 4LP
United Kingdom, Nottinghamshire Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
United Kingdom, Oxfordshire Oxford, Oxfordshire, United Kingdom, OX3 9DZ
United Kingdom, Salford Salford, United Kingdom, M6 8HD
United States, Alabama Birmingham, Alabama, United States, 35233
United States, Arizona Phoenix, Arizona, United States, 84018
United States, California Arcadia, California, United States, 91006
United States, California La Jolla, California, United States, 92037
United States, California Long Beach, California, United States, 90806
United States, California Los Angeles, California, United States, 90033
United States, California San Francisco, California, United States, 94158
United States, California Torrance, California, United States, 90502
United States, California West Hollywood, California, United States, 90048
United States, Colorado Basalt, Colorado, United States, 81621
United States, Colorado Denver, Colorado, United States, 80262
United States, Colorado Fort Collins, Colorado, United States, 80528
United States, Florida Boca Raton, Florida, United States, 33487
United States, Florida Maitland, Florida, United States, 32761
United States, Florida Naples, Florida, United States, 34105
United States, Florida Tampa, Florida, United States, 33609-4052
United States, Florida Tampa, Florida, United States, 33612
United States, Georgia Savannah, Georgia, United States, 31406
United States, Illinois Northbrook, Illinois, United States, 60062
United States, Kansas Kansas City, Kansas, United States, 66160-7321
United States, Kentucky Lexington, Kentucky, United States, 40509
United States, Massachusetts Boston, Massachusetts, United States, 02111
United States, Massachusetts Worcester, Massachusetts, United States, 01655
United States, Michigan Detroit, Michigan, United States, 48201
United States, Michigan Owosso, Michigan, United States, 48867
United States, Minnesota Minneapolis, Minnesota, United States, 55422
United States, Minnesota Rochester, Minnesota, United States, 55905
United States, Missouri St. Louis, Missouri, United States, 63131
United States, Nevada Las Vegas, Nevada, United States, 89106
United States, New Jersey Teaneck, New Jersey, United States, 07666
United States, New Mexico Albuquerque, New Mexico, United States, 87131
United States, New York New York, United States, 10029-6501
United States, New York Stony Brook, New York, United States, 11794
United States, North Carolina Raleigh, North Carolina, United States, 27607
United States, North Dakota Fargo, North Dakota, United States, 58103
United States, Ohio Cleveland, Ohio, United States, 44106
United States, Ohio Cleveland, Ohio, United States, 44195
United States, Ohio Columbus, Ohio, United States, 43235
United States, Ohio Dayton, Ohio, United States, 45417
United States, Ohio Westerville, Ohio, United States, 40382
United States, Oregon Portland, Oregon, United States, 97225
United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19107
United States, Pennsylvania Philadelphia, Pennsylvania, United States, 19104
United States, South Carolina Greer, South Carolina, United States, 29650
United States, South Carolina Greer, South Carolina, United States, 29651-1817
United States, Tennessee Cordova, Tennessee, United States, 38018
United States, Tennessee Franklin, Tennessee, United States, 37064
United States, Texas Houston, Texas, United States, 77030
United States, Texas San Antonio, Texas, United States, 78258
United States, Vermont Burlington, Vermont, United States, 05401
United States, Wisconsin Milwaukee, Wisconsin, United States, 53226